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We need more diverse stories and images being told because of nonsense like Snoop celebrating pimps and walking Black women down a red carpet like golden retrievers.
The absence of NR2E3 repressor function on cone-specific promoters very likely causes ESCS, and at least three different molecular mechanisms may be involved: 1) absence of NR2E3 protein because of nonsense mutations and aberrant splicing; 2) absence of DNA binding because of mutations in the DBD; 3) impaired corepressor binding because of mutations in the LBD.
In addition, we conclude that complete loss of merlin or large truncations of merlin because of nonsense or frameshift mutations might have a functional consequence.
It was previously reported that in a case with nonsense mutation the mutant mRNA was absent in lymphocytes because of nonsense mediated mRNA decay (NMD) and therefore postulated that haploinsufficiency alone can give rise to the PHA1 phenotype in patients with truncated mutations.
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We show that disruption of DISC1 near the site of the translocation results in decreased DISC1 protein levels because of nonsense-mediated decay of long splice variants.
However, mutant forms of LKB1 mRNAs can have a shortened half-life because of nonsense-mediated decay, which can potentially interfere with mutation detection (Abed et al, 2001).
This smaller isoform was initially described as caspase-10C, but its transcript is supposed to be untranslated because of nonsense-mediated mRNA decay.
The transcript level of Clark- w4 and 222-A-3 222-A-3 222-A-3ly lowas than that of Bay, probably becausubstantiallye-mediated mRNA decay, a surveilowere mechanism thanliminathatberrant mRNA transcripts that coftain premature stop codons [ 25].
Two of the human mutations are nonsense changes and the remaining two appear to lead to nonsense changes following splicing defects, strongly suggesting that ADAM9 is likely to be absent in these patients because of nonsense-mediated decay.
Scent is described as the Cinderella of the senses because a considerable amount of nonsense is written and talked about it.
But the single comfort of our underpaid, unequal and exploited industrial present is that in our local theatre of the class war a panicking government has seized for the weapon of nonsense, because the union movement is wielding the weight of public opinion.
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