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Twenty-three patients were excluded because of multiple gestations, structural or chromosomal abnormalities, or fetal death or for lack of available follow-up.
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We included only singleton gestations in the study because conventions for assigning gestational hCG to survivors of multiple gestations have not been set, maternal serum screening of multiple gestations appears much less common than for singleton gestations (53% compared to 65%), and sex-specific selection in utero among twins appears different than that among singletons (Catalano et al. 2009a).
Since many of the pregnancy complications observed could be due to their higher incidence of multiple gestations, we reanalyzed our data excluding those individuals with multiple gestations.
In the event of multiple gestations, the outcome of the first-born infant was recorded.
Neonates of multiple gestations and their parents will be randomised as a single family unit.
Five studies [ 40, 57, 58, 60, 61] included mother-infant pairs or dyads without mention of multiple gestations.
In studies that reported allocation of multiple gestations [ 23, 53], infants from one family were assigned to the same group.
This is a critical gap in our understanding, given the increasing prevalence of multiple gestations in HICs.
Clinical management and outcome of multiple gestation can be affected by chorionicity.
Conclusion: The risk of multiple gestation with controlled ovarian hyperstimulation/intrauterine insemination in this study was relatively low.
Besides prenatal complications, our data indicate a high frequency of multiple gestation births.
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