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The patients with a SALS diagnosis without a SOD1 gene mutation appeared as a more heterogeneous group possibly because of multiple disease pathways.
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This might be justified because cancer is not one disease but a conglomeration of multiple diseases, with widespread heterogeneity even within a single tumor type.
Importantly, our study demonstrates that patients with multiple chronic diseases do not drive overall primary health care use in Ontario because prevalence of multiple chronic diseases in the population remains low.
Detection, containment, and control of emerging infectious diseases in conflict situations are major challenges because of multiple risk factors that promote disease transmission and hinder control even more than those in many resource-poor settings.
Unlike in towns where providers manage a single disease programme, in rural areas, they manage multiple disease programmes because of human resource shortages.
Participants had established chronic obstructive pulmonary disease, ischaemic heart disease or chronic heart failure or were at high risk of developing such diseases because of multiple risk factors.
Utility values were drawn from a secondary source because it was not feasible to obtain primary data for multiple disease states within the context of this study.
However, quantitative analysis of all bone metastases is a time-consuming task because patients with advanced prostatic cancer usually have multiple disease sites.
The treatment of neurodegenerative diseases is difficult because of multiple etiologies and the interplay of genetics and environment as precipitating factors.
Some of the results of these studies have been difficult to interpret, perhaps because of multiple effects of the same cytokine at different stages of disease.
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