Lack of replication was not attributable to lack of power, because the post hoc type II errors of missing results of a magnitude as the reported by Briggs et al. [ 22] at the final stage of their analyses were <0.20, which is conventionally considered sufficient (corresponding to statistical power of 0.80).
However, these scores are rarely used to follow patients in clinical practice because they either employ extensive joint counts (DAS), their computation requires the use of calculators (DAS, DAS28, DAS28-CRP), or their results are not accessible for immediate decision making at the time of patient physician interaction because of missing laboratory results (DAS, DAS28, DAS28-CRP and SDAI).
One case-patient and corresponding matched controls were omitted because of missing laboratory results.
One hundred and two individual observations were dropped because of missing serological results.
Another 344 individuals were excluded because of missing laboratory results, 150 individuals because of missing data on CRP, and 6 individuals because of missing data on educational level.
An additional 24 children were excluded because of missing hemoglobin results, which led to a total of 858 children included in the final analysis.
These are less than 95 because of missing data resulting from participants not responding to certain questions.
Although 93% of patients (26/28) had multilobar pulmonary involvement and were likely to have ARDS, this diagnosis was not used as a variable because of missing blood gas results and pulmonary wedge pressures.
Two additional studies reported effects on erythema score, but because of missing SDs, their results could not be used in the meta-analysis.
However, in other cases, pedigree information has been erroneous, either because of missing parent information, resulting in gaps in the pedigree, or because of wrong parent information resulting in misidentified parents.
