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These related miRNAs always show similar or consistent patterns of deregulation, although they may have different levels of enrichment because of maturation and degradation mechanisms.
However, at later developmental stages, visual cortical hyperexcitability appears no longer to exercise a direct functional role in synesthetic experience, plausibly because of maturation and cortical specialization of the visual system [ 20].
This weak effect of growth evolution on body length can also be observed at other ages: length at age 3 years decreased little because of evolution, and although length at age 10 years showed a dramatic response, this was mainly because of maturation evolution (Fig. 4H).
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The challenge is to accurately and safely differentiate these taller young children, who will experience earlier cessation of growth because of earlier maturation from those on a healthy trajectory to becoming taller adults.
It also represents a high point in the evolution of load-bearing tissues because the rate of maturation, low density, tunability and robustness of its mechanical properties, as well as its resistance to moisture, among other properties.
After 48 h of infection (Figure 3B and C), MVA-B induced higher production of IL-7, IL-15, MCP-1/CCL2 and MIG/CXCL9 than uninfected MDDC, indicating that some mediators are secreted at later times post-infection and/or at low doses possibly because is necessary some degree of maturation to up regulate such mediators.
Interferons (IFNs) also play an active role in this process as demonstrated by the phenotype of IFN-β−/− mice, which have a reduction in circulating macrophages and granulocytes because of defective maturation of primitive bone marrow hematopoiesis [4].
Despite chemotherapy, nearly half of the patients with myelocytic leukemias will fall prey to the disease because of the maturation of multiresistant subclones of leukemia cells [ 38, 39].
Incompleteness of mRFP expression compared to the endogenous expression may in part be due to the delay in mRFP fluorescence because of slow maturation of mRFP as well as the additional step of transcriptional activation by Gal4-VP16.
Children of all ages are vulnerable to the adverse impacts of the HIV/AIDS epidemic, and children in middle childhood and adolescence are more likely to lose a parent to AIDS because of disease maturation.
Because ambergris needs this period of maturation in the open air, it couldn't be harvested from live sperm whales even in the days when hunting was sanctioned.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com