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Because of its roles in autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and Sjogren syndrome (SS), BLyS antagonists have been tested to treat SLE- and RA-like symptoms in mice and obtained optimistic results.
However, we were interested in this gene because of its roles in morphogenesis and synaptogenesis.
Because of its roles in mitochondrial function, pol γ has been studied extensively from a clinical and biomedical perspective.
Because of its roles in the transcriptional regulation of MMPs, Ets-1 is a candidate mediator of cancer invasion and metastasis.
SOX10 is of particular interest because of its roles as a marker of neural crest stem cells (NCSCs) and in the maintenance and migration of NCSCs (McKeown et al, 2005; Drerup et al, 2009; Miyahara et al, 2011).
AMPK, which promotes autophagy by activating TSC 1/2 and suppressing mTOR, has been implicated in an energy check point because of its roles in phosphorylating p53 and inducing cell cycle arrest following energy deprivation.
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A lack of magnesium upends sleep not only because of its role in serotonin production but also because it topples the sleep regulating hormone melatonin.
Alexander Brenner, the head of Berlin's Jewish community, opposed Degussa's involvement but said "it would be ridiculous" to stop construction because of its role.
miR17 expression has been explored not only because of its role in regulating BRCA1 but also because computational analysis indicated it as a regulator of APEX1/REF1.
Norway was targeted because of its role in Afghanistan.
The dopamine system has become famous because of its role in addiction.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com