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Among them, 39 patients (65.0%) were recruited because of insufficient response and 21 patients (35.0%) because of insufficient tolerance to their original antipsychotics.
Twelve percent (14/113) of patients were switched to OLAT, either because of insufficient response (four patients) or for safety reasons (10 patients).
The study of Vander Cruyssen and colleagues showed that the DAS28 correlated best with the decisions of rheumatologists to increase the infliximab dose because of insufficient response.
Five patients were excluded due to the fact that XELOX was given as second or third line treatment, and one patient was excluded because of insufficient response evaluation according to the RECIST criteria.
All other patient demographics and baseline characteristics were similar between treatment groups (table 1). 9 A total of 33 patients discontinued the study because of insufficient response, withdrawal of consent, loss to follow-up or other reasons (figure 1).
In ten patients, OLAT was added to voriconazole after an average of 12 days (range 3 35 days), either because of insufficient response (nine patients) or due to safety reasons (one patient, who received 3 days of fluconazole following "pyrexia"; the voriconazole dose was not changed).
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The harvest was not performed in one patient because of an insufficient response to the growth factor stimulation.
Male or female subjects ≥18 years of age diagnosed with OAG or OHT with an IOP ≥21 mmHg were eligible if they were being treated with an ophthalmic beta-blocker monotherapy and if, in the investigator's opinion, they required a change in ocular hypotensive therapy because of an insufficient response to treatment.
One patient withdrew from the study after 20 weeks because of insufficient clinical response.
In the axitinib/paclitaxel cohort, six patients discontinued study because of insufficient clinical response (n=3) or for other reasons (n=3).
In the gemcitabine/cisplatin cohort, 20 patients discontinued, including 10 because of insufficient clinical response, 6 because of AEs and 4 for other reasons.
More suggestions(15)
because of insufficient interest
because of insufficient lighting
because of insufficient investment
because of insufficient ridership
because of nonlinear response
because of insufficient venom
because of insufficient efficacy
because of insufficient description
because of insufficient labeling
because of insufficient sample
because of insufficient breathing
because of insufficient number
because of symbolic response
because of public response
because of hemodynamic response
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