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Because of insufficient coverage by surveillance systems, only a fraction of HAT cases are reported.
In other cases, variants can be missed because of insufficient coverage of the genomic regions.
Finally, genes expressed at a low level, including the aforementioned transcription factors, may be missing from our dataset because of insufficient coverage or normalization.
A total of 103,863 exons were included in the comparison; among those, 103,850 did not show CNVs by aCGH, whereas 102,798 exons were considered to have normal copy numbers based on MPS analysis; 962 exons were excluded because of insufficient coverage.
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The low number of reliably detected SNPs and small indels was not the result of insufficient coverage or lack of sequencing quality because we detected 1193 variants present in all sequenced samples that presumably represent errors in the reference sequence.
This allowed for the generation of new items in case of insufficient coverage.
Because of the insufficient coverage of this region of values the model was unable to predict molecules with low MP values, which constituted about 25%% molecules of the Bradley set.
For instance, somastatin (SST) was identified using the EST [GenBank: CK234915] because of insufficient genome coverage and sequencing errors.
It should be mentioned that for about 80% of the predicted rho-independent terminators for C. glutamicum no clear transcript end could be determined, either because of insufficient sequence coverage or because of a gradual and slow transcription drop-off.
Three intraoperative complications occurred in 3 patients (1.1%): 1 perforation of the endo button into the femur, 1 second screw tunnel because of insufficient anterior coverage, and 1 Kirschner wire breakage.
Finally, accurate prediction of NESs has been difficult because of the breadth and simultaneously, the insufficient coverage of the NES consensus.
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