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This application benefits from high diversity, because overlapping individual reads are likely to share informative SNPs, and errors can be more clearly identified because of high coverage.
Persons in this cohort were not offered routine childhood MMR and avoided mumps exposure because of high coverage in younger children.
The outbreaks occurred during March July 2013 and were almost completely confined to adults; only 1 child was infected, possibly because of high coverage of measles-containing vaccine among Beijing children.
Early evidence suggests that this aggressive strategy substantially reduced the rate of meningitis among persons in these age groups and in the general population because of high coverage and herd immunity (5 ).
BLAST comparison of this transcriptome with the existing B. orellana library database [ 14] and 21 homologous proteins previously isolated [ 12, 13, 33– 37], confirmed that our B. orellana assembly is reliable because of high coverage and identity (Additional file 1: Table S2 and Table S7).
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We performed read mapping and SNP calling with SOLiD Corona Lite and later switched to Bioscope (a pre-release version of v1.2), after the manufacturer advised that the Corona Lite SNP-caller (pre-release diBayes) was not designed for enriched samples (because of high coverages, steep coverage gradients and/or PCR duplicates).
These species were chosen because of their high coverage of genome sequencing, their assignment of all sequences to chromosomal locations, and because they cover a wide spectrum of genome sizes.
Second, supposing that they were misassembled in MHAP, they must be present in the PacBio reads, because of their high coverage of the genome (∼90× for the autosomes, 45× for the sex-chromosomes).
Because of the high coverage and accuracy of the linked files, the cancer risk estimates by social class can be considered reliable, and the large numbers of cases downplay the role of chance even in the case of relatively rare cancer forms.
We chose this platform because of its high coverage and accuracy relative to other platforms.
Primers A519 539, E969 983, E1063 1081, U515 and E517, are highly recommended because of their high coverage in almost all phyla.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com