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In addition, sensitivities are limited because of high background signals.
Nevertheless, the higher binding properties of FPRGD4 did not translate to improved results in vivo because of high background accumulation.
But researchers are still working to measure SO2 and CO2 at the same time, and measuring point sources of CO2 is challenging because of high background levels in the atmosphere.
After the mainshock, the EEW system did not work well for several hours because of high background noise from the coda waves of the mainshock and active aftershocks, and because of power failure and wiring disconnections.
Live imaging of cells in the presence of Alexa Fluor 647 did not allow detailed analysis of cell extensions because of high background fluorescence.
Sulfidoleukotrienes were considered significantly increased when above 163.8 pg/ml, a cut-off that was calculated from the mean plus 3*SD of negative stimulation controls (patient #54 excluded because of high background).
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Binding of such lipophilic compounds to membrane-resident proteins is difficult to measure and interpret because of high backgrounds in the measurements and small populations of membrane-resident receptors (Nadal et al. 2000; Powell et al. 1999), as well as possible binding to different-shaped binding pockets.
Immunofluorescent staining of interphase cells with anti-Dicer antibodies did not provide conclusive evidence in support of nucleolar localization of Dicer because of a high background staining of whole mount cells (data not shown).
The participants in that workshop strongly recommended that the NTP discontinues use of the F344/N because of its high background incidences of certain types of tumors (i.e., Leydig cell tumors and mononuclear cell leukemia), unresolved issues regarding its declining fertility, occurrence of sporadic seizures, and chylothorax.
MS/MS-identification of phosphotyrosine-containing proteins is hindered by the low abundance of phosphotyrosine-containing proteins [ 50], and MS-identification of phosphopeptides is also complicated by ion suppression effects because of the high background of nonphosphorylated peptides.
However, most existing methods for the detection of low-level DNA mutations are insufficient for clinical applications because of the high background of wild-type DNA.
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because of high blood
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because of high ticket
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