Sentence examples for because of functional constraints from inspiring English sources

Because of functional constraints on the structure of rRNA gene sequences, certain regions in rRNA genes that are in contact with other components in the ribosome are conserved, while sequences between the conserved regions mutate at faster rates.

Because of functional constraints of peptides, tri-SSRs with no frame shift mutations are preferable for coding regions [ 33].

In most cases, promoter regions will not overlap with the coding or UTR regions of neighbouring genes, both because of functional constraints and because transcription of the neighbour gene would interfere with transcription initiation at the promoter [ 1, 2].

This value is much higher than the unique CNSs in other lineages, suggesting that the observed higher number of CNSs in primates is not only solely because of the divergence time but also because of functional constraints.

We focused on the fact that coding regions (CDSs) generally differ from non-coding regions by exhibiting a characteristic substitution pattern because of functional constraints on the protein sequences.

This approach is based on the assumption that gene-coding regions are much less variable than intergenic regions because of functional constraints and are therefore more reliably matched between genome pairs.

This could explain the high substitution rates, because of a lack of functional constraints.

The accelerated substitutions of non-synonymous sites of WAP-coding regions may be explained by positive Darwinian selection or relaxation of functional constraints, because we observed statistically significant positive selection of the WAP coding regions of porcine trappin-3 and trappin-9 but no significant difference between dn and ds of other trappins (Table 3).

Cross-species DNA sequence comparison is an excellent tool for identifying these biologically important elements, because the level of evolutionary conservation is correlated to the extent of functional constraints.

The absence of a strong correlation between heteropecilly and heterotachy makes sense because the two heterogeneities do not apply on the same criteria: heterotachy is mainly due to loss or gain of functional constraints (i.e. variable strength of constraints), whereas heteropecilly is rather due to variation in the nature of functional constraints, not in their strength.

The more likely explanation is relaxation of functional constraints.