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Thus, even though the average filter effect across all genes is small, a small number of genes may produce very different hybridisation signals because of filter differences.
Thirteen treatments were stopped because of filter clotting, in all the remaining 87 filters stopping of treatment was caused by other reasons (surgery, diagnostic procedures, restored diuresis, death).
In our study, RCA-CVVH did not stop in any case because of filter clotting, as confirmed by the stability of filter drop pressure recorded throughout the circuit running time.
Among the cases with CRRT-related reasons for discontinuation, five treatments had to be stopped because of a technical malfunction of the CRRT device and four because of filter clotting before 72 h.
CVVHD runs had to be stopped prematurely because of filter clotting (two cases), a Catot/Caion ratio ≥2.5 (three cases), intervention/surgery (three cases), and planned stop (two cases).
One factor negatively affecting removal with CRRT is the frequent necessity to interrupt the procedure - for example, because of filter clotting, which occurs more frequently in CRRT than in IRRT.
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Thus, it was not clear how large gain in image quality can be provided because of filtering even in terms of output MSE lower bound.
However, there are also local degradations of visual quality when distortions introduced because of filtering are larger than positive effect of noise removal.
Residual noise and distortions because of filtering can become invisible after denoising if noise variance in original image is small enough and efficient filtering, e.g., vector or 3D filtering, is applied.
Fourth, using of modern visual quality metrics, we determine that for which levels of i.i.d. and spatially correlated noise the noise in original images or residual noise and distortions because of filtering in output images are practically invisible.
As it can be expected, visual quality improves because of filtering although this improvement is small for complex-structure images and it can reach up to 4 dB for simple-structure images.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com