The high mortality is mainly because of early development of systemic disease and resistance to currently available treatment strategies.
Despite the considerable research efforts expended to understand the causes of these EPL, few significant advances have been made in recent decades because of the complexities of early development.
Many pregnant women suffer miscarriages during early gestation, but the description of these early pregnancy losses (EPL) can be somewhat confusing because of the complexities of early development.
The earliest ontogenetic difference between sexes is an environmental one because the ambient temperature during sensitive periods of early development irreversibly determines phenotypic sex and, therefore, the sex ratio [1], [2].
Based on analogy with acetaminophen, BPA may be conjugated with sulfate rather than glucuronide in neonates because of the earlier development of sulfotransferases.
Ad serotype 5 has been the most widely used Ad vector because of earlier, historical development, its important safety profile and its remarkable capacity to induce strong, long-lasting and broad T-cell based immune responses, in particular CD8+ driven ones [ 2].
It is recommended that prophylactic surgery should be performed as soon as possible, simply because of the early development of cancer in BRCA mutation carriers.
Because of the need for the early development of a transport system within the embryo, the organs of the vascular system are among the first to appear and to assume their functional role.
Tartaric acid levels in ripe berries reflect the extent of synthesis during early development because there is negligible degradation at later stages.
However, the function of Atoh8 during early development is not clear because homozygous knockout causes embryonic lethality in mice.
Because of their critical influence on early development, maternal RNAs are believed to play an important role in the developmental differences among species [ 5, 7].
