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The epidemiological studies previously carried on the prevalence of PD in population exposed to environmental factors have produced controversial results, probably because of different trial design and different analysis methods.
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Although comparing the root distribution of the two datasets is difficult because of different field trial characteristics, age of trees, and sampling methods, the application of a modelling framework does allow a general comparison of the datasets in terms of calibrated model parameters.
Pfizer study ID numbers of these trials and ClinicalTrials.gov identifier numbers (where available) were as follows: 1008-105 [ 15] A0081056, NCT00645398 [ 16] A0081077, NCT00230776 [ 17] A0081100, NCT00333866 [ 18] An enriched enrolment randomised withdrawal trial, the "FREEDOM trial" [ 19], was not included in our analysis because it was of fundamentally different trial design [ 20].
Work status, when identified, was listed as an outcome but pooling of these data was also not possible because of different definitions used across trials.
Baseline demographics at the time of clinical trial entry could not be included in this analysis because different trials collected different demographic information.
The five animals represent the outcome of five different trials.
Consequently, it is not problematic that the calibration error changes across trials because data from different trials are corrected independently.
AEs from different trial programmes are difficult to compare because of differences in the methodology of collecting AEs.
The definition of myocardial infarction, which is summarised in table A in appendix 1, differed among included trials largely because of different criteria used to adjudicate peri-procedural events.
Comparing our quality-of-life findings with previous trials is difficult because of different methods and follow-up durations.
Random-effects models for the primary analysis were applied because clinical heterogeneity between trials was expected (because of different patient populations and intervention regimens).
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