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Unfortunately, the drug failed to receive U.S. Food and Drug Administration approval because of depressive side effects.
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Bipolar depression is the depressive side of the disorder that comes after or before the manic phase (when a person feels extremely happy and energetic).
This probably accounts for the depressive side of withdrawal symptoms (serotonin receptors in the brain are the target of antidepressant drugs such as Prozac).
"Possibly the comedy - the extroverted side - is a way of dealing with the depressive side.
Nacho's music springs from the dark, depressive side of Seattle that once birthed the grunge movement but his twisted lyricism is balanced by humor in the same way Nirvana's music once was.
Whether topiramate has any effect on the depressive side of bipolar illness is not yet know.
"Because comedians do frequently have a depressive side to them, and then if you combine that with who's working and who's not working…" Again, she seems to take herself aback: "This is generally an area I don't go into".
There was a series of events - "the list of horrors" - which he thinks precipitated his depressive side.
Tiptree flattered and flirted; she showed a moody and depressive side; she made fun of her own modus operandi.
He had this dark, depressive side".
Their father was a bit on the manic-depressive side, there had been episodes over the years.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com