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Well-known case studies describe physicians who coördinated care for a group of diabetics, only to see the program cancelled because of deleterious effects on the hospital sponsor from reduced admissions.
Also, I had overheard conversations in the hospital waiting room about other ovarian cancer patients dropping out because of deleterious side effects, some of which I experience.
LIV.52 has been withdrawn from the market because of deleterious effects in patients with liver disease.
Because of deleterious side effects with currently available drugs the search continues for novel effective and safe therapies.
The use of intravenous vasodilators to reduce pulmonary hypertension is limited because of deleterious side effects.
In our simulations, the Y chromosome was degenerating because of deleterious mutations reducing the effective population size of the Y.
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Because the rates of deleterious and advantageous mutation are different, this may affect the parameterization of the subfunctionalization and neofunctionalization models in a manner that was not considered.
Second, clonal interference drives the distribution of protein stabilities in the viral population far off equilibrium, because the frequencies of deleterious changes are enhanced by hitchhiking with beneficial changes in adaptive phenotypes (see Figure 5).
Another important challenge is that there will initially be a great deal of uncertainty in the interpretation of genetic information because the penetrance of deleterious alleles in the general population is unknown.
Haplodiploid Species: Haplodiploid species are less sensitive to inbreeding depression than equivalent diploid species, because of purging of deleterious alleles in haploid males (see Peer and Taborsky 2005; Frankham 2010).
However, Davies et al. [ 87] suggest that these measures should be adjusted upward 28-fold because approximately 96% of deleterious mutations are undetectable experimentally, a result that was corroborated with a different approach [ 48].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com