Sentence examples for because of clonal selection from inspiring English sources

Although docetaxel represents an important therapeutic milestone and is the current standard of care for metastatic hormone-refractory prostate cancer (HRPC), most patients eventually progress because of clonal selection of therapy-resistant cells or the development of cells with a drug-resistant phenotype.

Cyclical parthenogens (e.g. rotifers and cladocerans such as Daphnia) have an increased capacity for rapid local adaptation and priority effects because sexual reproduction is followed by multiple generations of clonal selection and massive egg bank formation.

Cyclical parthenogens (e.g. rotifers and cladocerans) have an increased capacity for rapid local adaptation over other breeding systems because of their frequent sexual reproduction followed by multiple generations of clonal selection [ 5] and persistent priority effects [ 8].

Most models of clonal selection in the Th cell compartment favor TCR affinity-based thresholds.

The theory is now sometimes known as Burnet's clonal selection theory, which overlooks the contributions of Ehrlich, Jerne, Talmage, and the contributions of Lederberg, who conceptualised the genetics of clonal selection.

A summary of clonal selection and propagation procedures is shown in Figure S1.

Pooled stable transfectants carrying either construct were used to minimize any potential effect of clonal selection.

The disappearance of TP53-mutated cells after chemotherapy in one case (patient 7) is clearly in favour of clonal selection.

Interestingly, when comparing the histological features of the secondary and tertiary transplanted tumors, the authors found evidence of clonal selection.

Rather than kinetic resistance, the resistance of cancer cells to chemotherapeutics may be a consequence of clonal selection.

Presumably, because of negative clonal selection and differences in homopolymer content in exons vs other genomic regions, exonic substitutions outnumbered indels, similar to what we observed in the MMR-deficient whole-genomes.