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Prostaglandin E2 (PGE2) is an important factor in the pathogenesis of periodontal disease because of bone resorbing activity and association with attachment loss.
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To preserve the tissue integrity and in response to physiological stimuli, bone is continually remodeled through the concerted activity of bone resorbing cells, the osteoclasts, which dissolve mature bone, and bone depositing cells, the osteoblasts, which lay down new bone.
Bone erosion in inflammatory arthritis depends on the recruitment and activation of bone resorbing cells, the osteoclasts.
We also observed a higher surface of bone resorbing pannus in AIA + HFD than in AIA rabbits.
On the basis of these results we conclude that gap-junctional communication is essential for the action of bone resorbing osteoclasts and for proper remodelling for bone.
Drug treatments in osteoporosis patients will slow down the activity of bone resorbing cells (osteoclasts) or stimulate the activity of bone forming cells (osteoblasts) or do both.
Long-term space flight and microgravity result in bone loss that can be explained by reduced activity of bone-forming cells (osteoblasts) and/or an increase in activity of bone resorbing cells (osteoclasts).
Therefore, intermittent administration increases the number of bone forming osteoblasts whereas continuous administration increases the number of bone resorbing osteoclasts (Dobnig et al 2005).
This is probably because of the in vivo action of AD on bone resorbing osteoclast cells.
Bone is capable of remodeling by bone resorbing osteoclasts, bone forming osteoblasts and osteocytes [ 15, 19, 22, 26].
The V-ATPase with a3 subunit is highly accumulated in the bone resorbing osteoclasts, and its deficiency causes severe osteopetrosis because of defective bone remodeling [24].
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