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Similarly, quantification of drug lost in control jars because of binding of drugs to the polypropylene container was not feasible.
We hypothesise that during the active phase of the disease, the levels of anti-GAG antibodies are reduced because of binding of these antibodies to GAGs released from the degrading cartilage.
Previous studies revealed that BRs have the ability to lower metal uptake in plants, probably because of binding of BRs with membrane proteins that enhance metabolic activities by detoxifying heavy metal stresses [ 53].
It was hypothesized that this effect might occur in part because of binding of TXA to the γ-aminobutyric acid (GABA) binding site of GABA-(A) receptors, as shown in membranes from rat cerebral cortex [ 21].
It has been shown in promyelocytic leukaemia cells that the transcriptional control of TOPK promoter is mostly because of binding of transcription factors E2F and CREB/ATF to two distinct binding sites within it (Nandi and Rapoport, 2006).
These pTyr-containing peptides are supposed to preferentially bind with the catalytic site as substrates, but to minimize potential competition because of binding of the pTyr peptide to the N-SH2 domain, we determined the kcat/ Km value, a measure of substrate specificity, under conditions where substrate concentrations were much lower than Km.
Similar(54)
Because any kind of binding of xenobiotics to estrogen or androgen receptors is undesirable, we pooled the results from studies with both receptor types for the identification of relevant structural alerts.
The pH effects may not be a concern because the comparison of binding of the ligand to nNOS and eNOS is made in the same pH range (∼6.0).
Thus, autolysis of MMP-2 slowed because of binding to CI [ 14], and substrate turnover, especially for short substrates, is enhanced by (GPO)10.
We did not use cotinine as a second confirmation means of abstinence because the binding of nicotine to antibodies might prolong the elimination of nicotine and its metabolite cotinine [17].
However, the drug-albumin complex formation is not a conditio sine qua non for an elevated therapeutic potency of boronated chlorins because the binding constants of the complexes of albumin with 2 and 5 were similar (our unpublished observation).
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