In addition, resistance to VEGFRs and mTOR blocking agents often arises even in responders, most likely because of altered signalling alterations.
Aged hearts are more vulnerable than mature hearts to reperfusion injury during cardiac surgery because of altered cardiomyocyte Ca2+ homeostasis.
Food insecurity can put children at greater risk of obesity because of altered food choices and nonuniform consumption patterns.
The low-fat dairy desserts are generally not so much appreciated as the corresponding products containing fat because of altered flavour and texture characteristics.
Despite bone mineral density (BMD) is usually normal or more often increased in these patients, fracture incidence is high, probably because of altered bone "quality".
Because of altered drug pharmacokinetics during pregnancy and the possibility of drug transfer across the placental barrier, the use of antibiotics during pregnancy should be approached with caution [7, 8].
Mountain meadows and other open habitats are much reduced in LNF as compared to historical coverage primarily because of altered fire regimes and reduced timber harvest (Kaufmann et al. 1998; Frost et al. 2007).
Although frequently claimed as the end-goal, restoration may often not be unachievable, because of altered hydrology, habitat fragmentation, contamination, climate change, prohibitive costs and other environmental and socio-economic boundary conditions.
