Most notably, mutations in one of the genes encoding eIF5a lead to slower decapping of mRNAs, perhaps because of alteration to translation initiation and/or translation elongation (Zuk and Jacobson 1998; Saini et al. 2009).
"Because of the alterations to memory that suggestiveness can cause," the court said, "it is incumbent on courts and law enforcement personnel to treat eyewitness memory just as carefully as they would other forms of trace evidence, like DNA, bloodstains, or fingerprints, the evidentiary value of which can be impaired or destroyed by contamination".
Reports by federal safety engineers who tested the furnaces show that they cause fires because of alterations Consolidated made to comply with California's regional smog control rules.
D2R-mediated changes to specific subsets of GABAergic interneurons are of great interest, because alterations to various subsets are key features in many neuropsychiatric disorders also involving D2Rs.
The conjugate 31c was also labeled with scandium-44 and further analyzed in vivo because of the minimal alterations to structure and geometry and very good radiochemical purity and stability.
Because of the minimal alterations to structure and geometry and very good radiochemical purity and stability (Table 6), the 44Sc-labeled DOTA-HPMA polymer 31c with the lowest DOTA incorporation and a short alkyl linker was chosen and evaluated in B16 tumor-bearing mice.
Recently, this was reported to be because of alterations in actin dynamics and the direct binding of mycolactone to Wiskott Aldrich syndrome protein (WASP) and neural WASP (N-WASP) (Guenin-Mace et al., 2013).
However, the presence of wild-type protein may indicate that p53 is functionally inactive because of alterations in the pathways that lead to its activation.
However, this does not seem to be because of alterations in the expression of ectopic hMdm2 cDNA, since different small mutations at distant sites of the protein (the NLS and the NoLS) prevent the detection of the 32 kDa band.
Many modifications are deleterious to protein function because of alterations in protein folding that reduce or eliminate functional activity (e.g. enzyme activity).
