Despite a typically good response to first-line combination chemotherapy, the prognosis for patients with advanced ovarian cancer remains poor because of acquired chemoresistance.
However, both conventional chemotherapy and targeted therapies can fail because of acquired drug resistance.
The risk for infection and disease decreased with age, probably because of acquired partial immunity.
Moreover, even patients with an initial clinical benefit will finally progress because of acquired resistance or for other reasons.
> Liver cirrhosis patients are very susceptible to bacterial infections because of acquired immune defects of both humoral and cell-mediated immunity and bacterial translocation [ 3, 19].
However, their benefits are limited by tumour recurrence in a significant proportion of initially drug-responsive breast cancer patients because of acquired anti-oestrogen resistance.
Infected animals that survive are not expected to experience higher than normal abortion rates in subsequent years, in any case, because of acquired immunity.
They are all stem-cell-derived clonal proliferative diseases whose shared and diverse phenotypic characteristics can be attributed to dysregulated signal transduction because of acquired somatic mutations [ 6].
The seroprevalence of MCPyV and TSPyV among children <13 years of age increased because of acquired infections, a finding consistent with reports that primary infections with these 2 viruses are ubiquitous in childhood (5, 7 ).
Unfortunately, 40%to50%0% of ER+ breast cancer patients either will not respond to endocrine therapy (that is, exhibit de novo resistance) or will have cancer recurrence because of acquired endocrine therapy resistance [ 2].
Stimulating old stem cells to grow more rapidly, perhaps by stress such as IR, puts stem cells at greater risk of becoming cancer cells because of acquired DNA damage.
