This interpretation is seen as conservative, because a prolongation of the time horizon from 3 years to the whole lifetime of the patients might well improve the cost-effectiveness of MARS by decreasing the costs per life year gained.
The outcome of this is a prolongation of the travelling time that might be unacceptable.
Because of this prolongation in survival, GC patients live longer, but have a greater possibility of developing multiple primary cancer (MPC).
Eliot had a point, however, especially in his contention that because of certain plotting problems in the play, especially the disproportion between Gertrude's guilt and her son's disgust, Hamlet's bafflement as to what action to take "is a prolongation of the bafflement of his creator in the face of his artistic problem".
Candidaemic patients needed a prolongation of mechanical ventilatory support of 10 days [ 8].
Silence, whether due to the official censorship regarding the war in Algeria or the social censorship of the experience of the Holocaust, comes off as a prolongation and repetition of trauma, a primary obstacle to self-realization and self-fulfillment.
There is "a prolongation of innocence there, a prolongation of childhood, that has to do with the Midwest being just a little bit farther from the rest of the world," Jonathan Franzen once said in an interview.
Cardiac adverse events, particularly the increase of heart rate and prolongation of the QT interval associated with polymorphic ventricular tachycardia (or torsade de pointes), can be serious, and the antimuscarinic agent terodiline was withdrawn from the market because of an association with QT prolongation [103].
4, 5, 21– 23 Still, a prolongation of PFS from IPC is considered clinically relevant, because it is reasonably associated with less disease-related symptoms and, thus, improved quality of life.
Rather than a prolongation of the action, extra-time periods took on the air of interludes.
