β-glucosidases are inhibited by the end-product glucose [ 49], and the β-glucosidase content is T. reesei enzymatic cocktails is often low [ 50], limiting the cellulose hydrolysis rate because of accumulation of cellobiose, a potent inhibitor of cellobiohydrolases.
OxyContin, made by Purdue Pharma, is attractive to drug abusers because it contains large quantities of a potent opioid pain killer, oxycodone.
TGF-β signaling plays an important role in the development of tumors because it is a potent inhibitor of cell proliferation in most cell types [ 4, 5].
Methane breakdown is a globally important process because "it keeps massive quantities of methane--a potent greenhouse gas--from reaching the overlying waters and atmosphere," says microbiologist David Valentine of the Scripps Institution of Oceanography in La Jolla, California.
This function appears to be independent of p38 MAPK because SB202190 (a potent p38MAPK inhibitor) is unable to reverse the inhibition of the progesterone receptor activity elicited by reducing Wip1 expression in MCF-7 cells.
However, in Pb-exposed individuals, δ-ALA levels in serum will be abnormally high because Pb, a potent inhibitor of erythrocyte δ-ALA dehydrase activity, prevents dimerization (Secchi et al. 1974).
Recently, DNA hypomethylation also has been hypothesized to be associated with the actions Hcy plays in vivo, because SAH, a potent inhibitor of cellular methylation, was found to be increased in HHcy [ 10].
Clinical issue BMI1 is an epigenetic gene regulator that has gained considerable interest in the field of stem cell biology because it is a potent inducer of neural stem cell self-renewal in vitro and in vivo.
Because PROK1 was a potent inducer of contractility of guinea pig ileum, our results indicate that elevated expression of PROK1 in the myometrium, with the onset of labor, may regulate contractions of smooth muscle cells, resulting in uterine contractions during labor.
This is of particular relevance because SAH is a potent product inhibitor of most transmethylation reactions (Yi et al. 2000), including those of arsenic (De Kimpe et al. 1999).
