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Exact(23)
But if the second exon, UUUU, were missing because of a mutation, the sequence would be read CAC-AAG-AAG.
People with the disease lack a necessary protein because of a mutation in a gene called SMN1.
In a series of studies, Dr. Kenyon, of the University of California, San Francisco, has created mutant roundworms that live six times longer than normal, largely because of a mutation in a single gene called daf-2.
Another quarter resisted the pesticide chlorsulphuron because of a mutation in the gene Csr1-1.
The team proposes this probably occurred because of a mutation in the DISC1 protein.
(Resistance usually develops when a small percentage of microbes escape an antibiotic because of a mutation and then those bacteria multiply).
Similar(35)
This is because the impact of a mutation is not solely limited to its effect upon activity.
However, because the effect of a mutation on the efficiency of mRNA splicing is often difficult to predict, many mutations that cause disease through an effect on splicing are likely to remain undiscovered.
In this view, phenotypic buffering is simply an inevitable side-effect – chaperones, after all, cannot tell which mutant proteins arose because of a DNA mutation or a translation error.
Three of those families were recruited because of prior knowledge of a mutation segregating within the family and were therefore excluded from this analysis.
The families of individuals who were recruited because of prior knowledge of a mutation segregating within the family were excluded (three in total), thus leaving a total of 188 families.
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