Fig. 3B shows that beside UbcH5b/c, UbcH6 and to a lesser extent UbcH13 are supporting axotrophin E3 ligase activity because we observed a linkage of ubiquitin to axotrophin.
12 Deaths within 365 days are derived through linkage between HES records and the Office of National Statistics and are available in this dataset for patients admitted to hospital between 1 April 2000 and 31 March 2005 because of a delay in linkage.
Yet despite multiple nuclei and centrosomes in a common cytoplasm, mitosis proceeds in an orderly fashion because of the linkage machinery to ensure a 1 1 paring between these two organelles.
Moreover, because of linkage disequilibrium (LD) and linkage, associations of DNA markers with quantitative trait loci (QTL) are expected to erode during successive meioses at a slower rate than pedigree relationships, which increases their utility across generations [ 5].
Because of strong linkage within a chromosome, we only evaluate pairs of markers that reside on different chromosomes.
These interference effects are possible because of an extensive genetic linkage across influenza's HA (Strelkowa and Lässig, 2012) and arise from variation in the background fitness of viral strains and from variation in the fitness effects of subsequent mutations.
A QTL analysis does not allow conclusions on whether the clustering of QTL is because of the pleiotropic effects of a major gene or because of close linkage of several genes (Erickson et al. 2004).
First, that it is just a statistical blip, possibly owing to some subtle bias in the original data set (note for example, that MST1R was analysed as a potential receptor because of its linkage to MST [ 22]).
Even if efforts to show an association between viral-induced disease susceptibility and OAS1 and/or RNASEL SNPs are successful, it may prove difficult to unambiguously identify a single causal SNP because of potential linkage disequilibrium at these loci.
Prediction of intrauterine growth disorders represents a compelling challenge for the modern obstetrics because of their linkage with both adverse perinatal outcomes and long-terms effects on good health.
