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Thus the Zmf3' h1 expression detected in P1 ww silks is because of a functional p2 gene [ 13].
Therefore, while it appears that IFN production in animals does not require TLR3 signaling, most likely because of a functional RLR system, it is clear that this receptor does play a role in the innate and adaptive immune responses.
Loss or depletion of VAPB activity in zebrafish, worms and mice induce a relatively mild phenotype possibly because of a functional redundancy between closely related VAP proteins in these models (Kabashi et al., 2013; Han et al., 2012).
Nine were not offered surgery because the seizure-onset zone was too large or not defined with sufficient precision to delineate the resection, and for one patient surgery was contraindicated because of a functional risk for language.
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Imprinted genes can have a significant role in disease because imposition of a functional haploid state at imprinted loci allows a single mutation event to be unopposed, giving it greater potential to affect gene function.
Intriguingly, the MMP-2 deficiency phenotype is counterintuitive because loss of a functional protease would be predicted to lead to a decrease in resorption and, therefore, to bone overgrowth.
This study focussed on the Hepa-1 c4 mouse tumour, a well-known model in which HIF-1 activation does not take place because of absence of a functional HIF-1β protein.
These DcRs do not induce apoptosis because of the absence of a functional DD (Ashkenazi, 2008).
Because selection demands expression of a functional ry gene, we confirmed that M{ ry +}6E; ry larvae survive purine selection.
This situation could be advantageous to some extent, because even partial restoration of a functional protein might correct the dystrophic phenotype.
Because of their lack of a functional immune system, the mice do not reject the implants, and this allows study of the invasive behaviour of the fibroblasts in the absence of other human cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com