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This pathway is so named because mutations in these genes lead to late flowering in all photoperiods due to the elevated FLC expression (reviewed in [2]).
The two genes are used because mutations in these genes have been found to cause certain diseases.
To date, 17 different genes in Drosophila are classified as PcG members because mutations in these genes cause misexpression of HOX genes (reviewed in Schwartz and Pirrotta, 2007).
Previous studies have analysed PNETs with ATRX and DAXX loss in a single cohort, because mutations in these genes are predominantly mutually exclusive.
There has been continued interest in finding new members of the TTFL not only for better understanding the mammalian circadian clock, but also because mutations in these core genes have been linked to several disorders [ 7].
At the same time, we determined that some genes previously reported as drivers were not significant by the new analysis because mutations in these genes occurred mainly in tumors with large background mutation rates.
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This region is clearly important for the catalytic cycle because mutations in the highly conserved residues in these regions in the human copper-transporting P-type ATPases result in debilitating hepatic and neurodegenerative diseases [ 47].
SERPINA1 was selected for further investigation because mutations in the SERPINA1 gene cause α1-anti-trypsin deficiency48,49, which makes it a target for therapeutic gene editing.
Nedivi and colleagues found that a protein known as CPG2 is key to this regulation, which is notable because mutations in the human version of CPG2 have been previously linked to bipolar disorder.
Dr. June said the research was the first successful targeting of a defect in a gene called KRAS, and is important because mutations in the gene are so common.
Although loss of any of the Elongator subunits is sufficient to disrupt function of the complex13, we used an Ikbkap/Elp1 knockout, because mutations in the human gene cause FD23.
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because innovations in these
because cases in these
because readmissions in these
because fees in these
because individuals in these
because deficiencies in these
because legislators in these
because investments in these
because princes in these
because changes in these
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com