Sentence examples for because most variants are from inspiring English sources

Because most variants are individually rare, achieving adequate statistical power requires a design where additional copies of the variant of interest can be sampled (perhaps in a family study or in a founder population) or the ability to combine and evaluate groups of variants likely to have similar function (86).

Overall, this is a consequence of most SNPs being redundant because of linkage disequilibrium and because they are not very informative, since most variants are rare.

Most variants are associated with the M470 allele in several European populations.

Most variants are predicted above 95% accuracy.

Because most rare variants are recent and located on long haplotypes, this shows that FImpute can exploit longer haplotypes (of closer relatives) quite efficiently.

We would not restrict future studies to de novo variants, however, because most rare variants are inherited and may have enhanced impact in the context of a 22q11.2 deletion (Stark et al. 2008; Forstner et al. 2013; Schofield et al. 2011; Brzustowicz and Bassett 2012; Merico et al. 2014).

However, because most variants and their proxies are non-coding, it is generally difficult to identify the causal genes.

Because the most common variants are SNPs, the term is often abused as a synonym for genetic sequence variation.

The lack of ciliary localization is not a result of increased protein degradation because most truncated Gli2 variants are expressed at higher levels than the wild type protein (Fig. S1A C).

Because most of the variants were discovered and validated in Caucasian populations, the genetic risk score was created only for Caucasian study participants.

Most of these variants are sites on the DNA where one unit is changed to another.