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Maintaining stability is a major constraint in protein evolution because most mutations are destabilizing.
A high mutation rate is usually associated with a fitness cost, because most mutations are deleterious.
Since all cell lines experience mutations, and because most mutations are detrimental, a clonal population with no HGT will deteriorate over the long term.
For most disorders, the gene(s) in which causative mutations lie are known but, because most mutations are unique to a family or individual, their identification may take several weeks.
The second explanation holds that evolution only selects against insufficient stability, but that proteins typically are marginally stable because most mutations are destabilizing and so extra stability is rapidly eroded by functionally neutral but destabilizing mutations (Taverna and Goldstein, 2002; Bloom et al., 2007).
Most chemo drugs developed in these two waves are mainly genotoxic, not only because they mainly target genomic DNA or some components that affect or are needed for DNA synthesis or repair 64 but also because most mutations are deleterious 65.
Similar(54)
This is because all mutations start at a low frequency, and most mutations are lost before reaching substantial allele frequencies.
According to this idea, most mutations are either harmful (and will quickly disappear from the population because those bearing them die) or irrelevant.
Although most mutations are deleterious, the exceptions are the raw material of evolution.
In the presence of regulators, most mutations are deleterious.
Most mutations are point mutations.
More suggestions(16)
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