Most mutational studies, however, have been preoccupied with the prevalence of somatic mutations in a specific single candidate gene in relatively small colorectal cancer patient cohorts.
While most mutational studies of the Nef-AP-2 interaction focused on the Nef central loop, one face of helix H3, including residues Gln104 and Asp108, contacts AP-2.
Consistent with our assumption, several mutational studies done on human CNTs show that most of the residues that we believe are important in the inward-facing conformation are also important for the binding and transport of nucleosides.
However, mutational studies by Piccolo's group showed that the most important recipient lysine for mono-ubiquitination is the neighboring K519 [ 34].
Such master regulators are infrequently mutated and thus evade detection by conventional mutational studies.
These mutational studies also revealed that the first TRE was the most powerful one in mediating a stimulatory effect on the SERCa2 gene.
Sequence conservation and mutational studies in the Per1 family [ 10] suggest that most members of this superfamily are metal-dependent hydrolases.
This is because current experimental data, based on ssNMR, cryo-EM, fiber diffraction, and mutational studies, are unable to provide such high resolution detail.
Although the antimicrobial spectrum of ABF-2 was investigated, structural and mutational studies of ABF-2 have not yet been conducted because of the low yield of ABF-2 in P. pastris (Kato et al. 2002).
Parvari, R. et al. Glycogen storage disease type 1a in Israel: biochemical, clinical, and mutational studies.
