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However, caution is required with such comparisons because many studies did not accurately explain the compliance criteria they used.

Thus, the controversial results related to helminth- Plasmodium coinfection in humans could be explained because many studies did not consider critical features of the helminth parasite biology.

The quality ratings of each study according to NOS criteria are listed in Table 2. Given the comparability, the quality was relatively low because many studies did not report on the control for RA, an essential potential confounder.

Its relative importance to explain discontinuation in the midst of the typical ART regimen (i.e. within first three cycles) is difficult to assess because many studies did not differentiate it from the psychological burden of treatment.

But at this stage we cannot exclude that this observation represents an ascertainment bias because many studies did not perform PINK1 dosage analyses and therefore might have missed CNVs in their patient groups.

Small-effect QTL are only reliably detected when marker density is high and sample size is large [ 30, 31]; therefore, because many studies did not have a high marker density or large sample size, the number of small-effect QTL is likely underestimated.

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Similar(53)

However, because many studies do not directly implicate PLA2 inhibition by quinacrine as the mechanism of NF-κB inhibition and in light of more recent investigations challenging the notion that quinacrine acts primarily as an inhibitor of PLA2 [ 200, 253, 266], quinacrine's effect is presumably, at least partially, due to NF-κB inactivation via a mechanism other than PLA2 inhibition.

Many studies did not report these values.

While we determined a priori to focus on change values because scoping of the literature indicated that many of the possibly eligible studies were small, many studies did not report change values.

Many, many studies do not replicate.

Unfortunately, many studies do not provide data of HbA1c.

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