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Because many randomized studies between different TKA concepts generally fail to show superiority of a particular design, we hypothesized that these seemingly similar designs would not lead to any difference in clinical outcome.
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The efficacy of catheters whose outer surface is impregnated with chlorhexidine and silver sulfadiazine was tested in many randomized studies in the 1990s.
Corn oil has been used as placebo in many randomized studies on n-3 PUFAs in CVD.
We chose 4±1 days because many randomized trials using T2-weighted MRI as an efficacy end point performed MRI 3 to 5 days after MI.
Many randomized comparative studies on SME in T2D have been conducted.
The optimal therapy for desmoid tumors remains controversial because large randomized studies are not abundant due to the rarity of such tumors.
Finally, only studies of prospective nature have been analyzed because no randomized studies have been published in this setting.
An optimal treatment for primary SCC of the rectum has not been established because of the lack of randomized studies.
Because of small numbers of patients, randomized studies will be difficult to conduct.
Debate persists, despite many randomized trials, perhaps because BM patients are a heterogeneous population.
Despite the fact that meta-analysis is traditionally used to combine results from randomized studies, such as randomized control trials, the use of meta-analysis to combine results from observational studies is becoming widespread because of the many issues in public health which cannot be studied without the use of observational designs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com