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Because many mutations will lead to loss of catalytic activity, the evolution of regulatory proteins from "dead" enzymes might be quite common.
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Because population size post self-renewal will be large, many mutations will be present and strong selection will produce many different compensatory alleles.
Therefore, no information is usually available on alternative splicing and many mutations will be missed [ 12].
This means that many mutations will not effect the phenotype and therefore will not be selected against.
We suspect that the conditional model may be better because many mutations could be compensating for other mutations driven by HLA immune pressure.
This is because many mutations in text do not exactly follow the HGVS nomenclature.
Because many mutations compromise PRC2 function drugs antagonizing this defect hold great promise.
Obviously, many nonsynonymous mutations will have been gradually eliminated due to their deleterious effect.
But flus pick up many mutations, and there will be no proof of protection until the C.D.C. can test stored blood serum containing flu shotantibodies against the new virus.
"Such genes will be quickly selected in males because new beneficial mutations will be quickly apparent".
Negative epistasis will prevent the evolution of resistance, because successive resistance mutations will aggravate each other's' costs.
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