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The smaller sample size is a study limitation because large studies produce narrow confidence intervals and more precise results.
23 24 25 This is because large studies in our review had relatively similar results to other studies and to the summary meta-analysis effect.
Despite experimental evidence, concerns regarding the effects of PEEP on splanchnic perfusion remain theoretical because large studies in humans are lacking.
Nonetheless, optimism is in the air, because large studies of many individuals and genetic markers seem to finally be revealing some of the genetic factors behind these common diseases [ 1].
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Calibration statistics (specially H-L goodness-of-fit statistics) present several problems, mainly the fact that they are very sensitive to larger sample sizes because larger studies have more power to detect departures from perfect calibration [ 10, 46].
Similar results were reported by the Spanish Collaborative Study of Congenital Malformations [ 57] and by two additional studies [ 59, 61], but a reporting bias might exist because several large studies found no statistically increased rate of oral clefts [ 60, 63].
Both were chosen because they are large studies with long-follow-up periods and carefully collected information, and because the relative risk estimates were multivariate adjusted.
A15 SCIENCE/HEALTH Hormone Research on Hold Researchers working on hormone replacement therapy have been forced to discontinue large studies because of risks from the drugs.
However, this hypothesis has not been tested directly because there are no large studies providing radiologic-pathologic correlation within the 22q11DS population specifically.
In addition, we excluded several large studies because their results could not be synthesized in our meta-analysis due to the way the results were reported.
However, the bulletin noted, controversy continues because one large study has indicated a slightly increased breast cancer risk at a young age related to oral contraceptives.
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