For molecules II and IIIb, both of which have twisted conformations, geometry optimisations failed because large changes in the molecular geometries were causing excited states to cross during the optimisation processes.
The fact that in our model recombination has only a weak effect on virus load, however, is compatible with strong selective pressures on escape mutants, as observed experimentally [23], [43] [47], because large changes in viral fitness in vivo do not necessarily induce substantial changes in virus load [48], [49].
The distinctions in ash contents can be explained by the different sampling durations because of large changes in emitted particulate mass, due to the high differences in particle size and number emissions.
Unlike leaf-level PRI, stand-level PRI was not clearly related to the Car/Chl ratio, presumably because the large changes in canopy structure (affecting stand Chl and green LAI) had a dominant influence on PRI over this time frame.
A few mats did show large changes, likely because of large changes in abundance in Elaphoglossum, either through high ramet mortality or recruitment.
In addition, many estuaries are highly urbanized and reference conditions are difficult or impossible to specify because of large changes in habitat, water diversion, and the introduction of exotic species (Nichols et al. 1986).
Because openness comes with large changes in the quantity and quality of available products, it is not surprising that during this period, we may have experienced substantial increases in economic well-being not fully reflected in the standard statistics.
Because many DNA binding drugs exhibit large changes in absorbance or fluorescence on binding, these changes are commonly used to determine the distribution of free and bound drug in solution to construct binding isotherms that may be used to obtain binding constants.
Foraminifera present a unique system for studying nuclear dynamics because these single-celled organisms undergo large changes in nuclear and cell size during their life cycle.
Consequently, infrared cooling by O changes very little even with large changes in temperature because of the relatively small argument (i.e., small energy at 63 µm) in the exponential [ Mlynczak et al., 2005].
Because such changes are accompanied by large changes in gene content, they often have a substantial effect on organismal fitness and highly variable fixation probabilities, and therefore, their incidence cannot fully portray the underlying pattern of mutational events.
