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Because CHO-GPAT1 cells have higher levels of LPA and TAG, we also expected to find increased DAG content, but DAG was 50% lower in the overexpressing cell line, perhaps because it was rapidly converted to TAG [12].
An explanation for this phenomenon is that, although the production of GST-P1 was enhanced in cancer, it did not show because it was rapidly extruded into the blood by an unknown mechanism operational only in cancer cells.
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Under normal conditions, the amount of RcsA protein is limited by its low synthesis level and because it is rapidly degraded by a Lon protease.
Interestingly, although the biosynthesis of glycine increased in these transformed cells, its pool size actually decreased because it is rapidly consumed for glutathione synthesis.
Ingested on its own, it has no effect on humans, because it is rapidly degraded by an enzyme in the gut, monoamine oxidase.
Although 2-deoxyglucose is often described as an inhibitor of glycolysis, its major effect may be to accelerate ATP consumption, because it is rapidly phosphorylated within the cell to 2-deoxyglucose 6-phosphate.
The action of cyclic AMP is brief because it is rapidly degraded by specific enzymes.
This is down to it having a very short atmospheric lifetime, of the order of hours to days, because it is rapidly removed as rain and snow.
Vinylidene chloride is produced by the reaction of 1,1,2-trichloroethane (itself derived from acetylene or ethylene) with lime or with caustic soda; it usually is prepared only as it is needed because it is rapidly attacked by oxygen to form peroxides that catalyze the formation of undesired polymers.
However, during long-term electrolyses, hydroxylamine is not detected and presumably because it is rapidly reduced to ammonia.
A search of the literature failed to reveal the isolation and identification of TCDD-Py in the environment, either because it is not formed in detectable amounts, because it is rapidly degraded, or because it has not been analyzed for.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com