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Curating gene information is the most time-consuming aspect of CTD biocuration because it typically requires access to the full text to resolve species information and the official gene symbol (using synonyms, alternative names, reactive monoclonal antibodies, DNA sequences, derived RT-PCR primers, accession identifiers or citations mentioned by the authors).
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It typically requires a great deal of water, along with pesticides and fertilizers.
It typically requires a complex partnership with social-service workers.
It could be because "software development typically requires large upfront fixed costs," meaning that firms that are already pretty large are the ones who can afford to invest in it.
Because isolation typically requires plaque formation and growth in the laboratory, some naturally occurring phages may escape isolation using standard methods.
This is often a difficult task, because superior production performance typically requires a combination of multiple targets, whereby the complex metabolic networks complicate straightforward identification.
This is because the dream island getaway typically requires endless maintenance and development work.
We note that next-generation sequencing of segregant pools greatly facilitated the rapid identification of the dominant alleles described here, because identification of dominant mutations typically requires either arduous construction of a genomic library or, alternatively, painstaking work to map the relevant variant (Forsburg 2001).
We did not include tree-based and hybrid algorithms because ortholog prediction on large datasets typically requires faster algorithms, and because the reliance of these algorithms on knowledge of the gene family (e.g., [18]) or species phylogeny (e.g., [19]) can render them inappropriate for downstream phylogenetic studies (but see [49]).
Long standing social rules and conventions are often clear and precise, as well as more rigid and entrenched than written ones, if only because their elimination, alteration or re-interpretation typically requires widespread changes in traditional attitudes, beliefs and behaviour.
Because most nonliving materials lack this complexity, repair typically requires human intervention.
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