The prevention of mitotic arrest associated apoptosis is likely a key event in arsenic-induced carcinogenesis because it predisposes cells to aneuploidy.
While initially believed to be a beneficial adaptation to stress, mounting clinical and experimental evidence indicate that hypertrophy is maladaptive because it predisposes patients to myocardial infarction, lethal arrhythmia, and heart failure (reviewed in [1]).
It predisposes us to expect the answer to be a sentient being, not unlike ourselves, "whom" we're trying to identify.
It predisposes Fitbit users to think that walking 10,000 steps daily is a reasonable, attainable goal.
It could be a gene that, defective in some way, predisposes a person to disease.
Ho and others argue (cited in Straub et al., 1997) that low individualism (collectivistic culture) possibly predisposes a culture against CMCs, because these media mute the group effect.
A "thrifty genotype" may confer an advantage in an energy-poor environment, which would become disadvantageous in an energy-dense environment because it would predispose to increased accumulation of adipose tissue.
Second, acinar-ductal transdifferentiation is clinically significant because it may predispose to the development of neoplasia [13].
In this respect, the higher frequency of polymorphisms in the PTPN22 susceptibility gene is of interest because it may predispose to the formation of autoreactive lymphocytes (14).
In diabetes, abnormalities of the autonomic nervous system (ANS) represent one important complication of the disease (1) because it can predispose to severe cardiovascular events (2, 3).
Cardiovascular disease must be considered because it may predispose to "vascular depression", characterized by late onset, psychomotor retardation, poor insight, and cognitive impairment (Alexopoulos et al 1997).
