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Speculating on a possible mechanism of such a feedback loop, one may suppose that one of its important components could be Fgf8, because it is upregulated by Agrs and since its activity is critical for the expression of Ras-dva1.
A BR-repressed gene, At4g18010, was chosen to represent Group 2 genes because it is upregulated in RD26OX and its promoter contains a BRRE site at −405 bp relative to the transcription start site (Supplementary Fig. 7a).
αvβ3-integrin has emerged as a key anti-angiogenic therapeutic target because it is upregulated in the vasculature of solid tumours, but its expression is low in quiescent vasculature (Brooks et al., 1994).
HvFT1 and HvFT2 are also likely to be flowering promoters because they can act as such in rice [75] but HvFT1 was thought to be the most likely orthologue of FT because it is upregulated at the floral transition [71].
Id1 is a promising therapeutic target because it is upregulated in high-grade gliomas and more specifically in GSCs.
Soluble N-cadherin (sN-cad), however, may be a very sensitive circulating marker, because it is upregulated in cancer cells and in stromal myofibroblasts.
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HSP30 is notable because it was upregulated by 1250.1-fold in the highest temperature group.
CCN4, the first cloned member of the WISP proteins was discovered because it was upregulated in the mouse mammary epithelial cell line C57MG transformed by Wnt-1 [ 2].
Because CD40 is upregulated in many cancers it is a potential target for anti-cancer therapy.
Because PGRMC1 is upregulated in the cells close to the necrotic area, it conceivably plays a role in this phenomenon.
DNA topoisomerase I is a key target for anticancer therapy because of its crucial role in DNA metabolism and because it is often upregulated in cancer cells (O'Leary and Muggia, 1998; Bailly, 2000; Garcia-Carbonero and Supko, 2002).
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Justyna Jupowicz-Kozak
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