For complex systems, SAS is advantageous compared to other methods because it allows studying the material in various solvents and environments; it is possible to characterize changes on the nanometer scale in situ and in a mostly nondestructive manner.
This system is clinically relevant because it allows study of the immediate or initial response of adult whole BM to the invasion of MM cells and provides another platform for unraveling the mechanisms by which MM cells escape immune surveillance.
In this context cardiopulmonary bypass (CPB) is appealing methodologically because it allows the study of preventive interventions [ 4- 6].
Directed evolution is a powerful tool to address these questions and explore adaptive landscapes because it allows the study of evolution in a highly controlled setup (Peisajovich and Tawfik, 2007; Romero and Arnold, 2009; Kawecki et al., 2012).
A qualitative study with individual in-depth interviews under a Grounded Theory approach was chosen because it allows for unconstrained study of the range and experiential aspects of target perceptions, behaviours and underlying issues [ 24, 25].
The invention, known as the glucose insulin clamp, gave doctors the ability, for the first time, to quantify insulin sensitivity and insulin secretion in human beings, which is important because it allows researchers to study new drugs and other interventions for people with Type 2 diabetes.
In this context, APL is of special interest because it allows one to study directly the development of an aggressive synovial-like membrane from the bone marrow.
Metagenomics has gained popularity because it allows researchers to study (the large amount of) microbes that cannot be cultured (Amann et al., 1995) and their role in the environment, for instance in term of interaction with other organisms.
Thus, the BFMDRS as the most frequently employed scale is valuable because it allows comparison with other studies, although it might not adequately reflect changes at all levels of severity.
