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It is especially appealing when symptoms are refractory to high doses of benzodiazepines, because it acts through a GABA-independent pathway.
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This is partly because it acts allosterically through FKBP12 rather than mTOR itself, and thus does not completely inhibit mTORC1 and mTORC2.
If it acts at all, it acts "through its partners and others".
It acts through buildings, not through theories.
TiVo (barely) survives because it acts as a smart VCR.
For this reason, another RASSF family member, NORE1A/RASSF5, was studied, because it acts together with RASSF1A to inhibit the proliferative stimulation induced by Ras and to promote apoptosis through activation of the MST1 kinase.
It acts predominantly through its melatonin MT1 receptor.
It primarily acts through the generation of ROS.
Because Decorin acts through EGFR, we speculated that we might see a difference in DCN expression between CRCs with KRAS mutations and CRCs without them.
Because Dot1 behaved similarly in both the barrier and desilencing assays, it seems likely that it acts in both assays through a common mechanism.
One explanation for Wapl's ability to act substoichiometrically is that it acts catalytically, modifying cohesin through transient interactions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com