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This is probably because increased stimulation of postsynaptic 5-HT1A receptors by 5-HT in the dorsal hippocampus and cortical areas results in hyperpolarization of these target neurons, making them less likely to fire an action potential [ 46].
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However, in various pathological disorders or after medical treatments, the homeostasis between proliferation and cell death can become substantially disturbed, resulting in loss of epithelial integrity and local inflammation because of the increased stimulation of the immune system by the products of the intestinal flora.
For example, newer antidepressants are intended to cause increased stimulation of the neurotransmitter system called serotonin.
Increasing stimulation frequency or release probability both tend to increase the proportion of τslow and of asynchronous release, whereas that of τfast decreases.
There are three kinds of interactions: no change, decreased, or increased after stimulation of CD4+ T cells.
Because electrical stimulation increased the fraction of cells with nuclear senescence as well as apoptosis in LMNAR225X/WT dermal fibroblasts, we further tested whether LMNAR225X/WT iPSC-CMs exhibited similar susceptibility to electrical stimulation.
Optogenetic stimulation of fear acquisition neurons increased fear, while stimulation of extinction neurons suppressed fear and prevented spontaneous recovery.
This approach was selected because the increased formation of Fos protein, 1 to 2 h after stimulation, correlates with increased neural activity in a wide range of neural systems [ 17, 18].
Hypergravity stimulation increased the thickness of cell walls and suppressed xyloglucan breakdown regardless of direction.
Fibres are water-holding and therefore will increase stool weight; however, colonic transit time is reduced because of stimulation of peristalsis [ 23, 24].
IL-1β stimulation increased the release of all three MMPs.
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