Coleen Murphy, a molecular biologist at Princeton University, and colleagues found that as C. elegans ages, its oocytes, or unfertilized eggs, start to degrade because of increased secretion of a protein called transforming growth factor beta, or TGF-beta.
Because low testosterone triggers increased secretion of luteinizing hormone, which stimulates Leydig cell testosterone production, the researchers checked whether there was an initial MBP-associated suppression in testosterone production.
Because miR-1246 wableble to induce increased secretion of TGF-β from M2 macrophages (Supplementary Fig. 7a), we propose a molecular model (Fig. 7e), where exosomes carrying miR-1246 are being released from mutp53 colon tumor cells.
Increased secretion of ACTH because of a corticotroph tumour or corticotroph hyperplasia causes adrenocortical hyperfunction, which in turn causes the constellation of symptoms and signs called Cushing syndrome.
To explain this, Dr. Javert turned to psychobiological theory, arguing that stress caused increased secretion of adrenaline.
Monounsaturated fatty acid diets improve glycemic tolerance through increased secretion of glucagon-like peptide-1.
Supplementary Figure 6 Increased secretion of inflammatory cytokines by TIM-3-deficient leukocytes.
The adrenal type develops because of an inborn error in the metabolism of the adrenal hormone cortisol that leads to an increased secretion of corticotropin (ACTH) and consequent excessive secretion of androgens (male sex hormones).
In addition, they increased secretion of suppressive IL-10.
In addition to increased secretion of cortisol by the adrenal cortex, activation of the fight-or-flight response causes increased secretion of glucagon by the islet cells of the pancreas and increased secretion of catecholamines (i.e., epinephrine and norepinephrine) by the adrenal medulla.
