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Because increased expression of closely related cIAP-2 might counterbalance the loss of functional cIAP-1 [33], the expression level of cIAP-2 was checked by immuoblot analysis.
Because increased expression of HSP27 is observed in cells that survive ischemic insults [90], it is not far-fetched to suggest that the induction of these chaperones might occur in cells destined to survive against METH-induced apoptosis.
Because increased expression of cathepsin proteases is significantly correlated with more aggressive tumors and poorer prognosis, inhibition of cathepsin activity may reduce tumor invasion and growth.
Because increased expression of TNF-α was not detected after treatment with doxorubicin, vincristine, or both, we did not use an inhibitor of the TNF-α pathway.
In this context hnf4a became particularly interesting because increased expression of this gene was already observed 8 hours into the experiment but at no time-point thereafter.
This choice was made because increased expression of type I interferon-inducible mRNAs is a direct molecular consequence of increased expression of IFNα proteins, and because type I interferon-induced mRNAs are easy to measure by either RT-PCR or microarray-based technologies and demonstrate concordant overexpression in blood and involved tissue in SLE [ 38].
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Memory T cells have an increased capacity to bind to inflamed endothelium because of increased expression of adhesion molecules and chemokine receptors [ 9].
Hypoxia as a physiological phenomenon exists in tumors.33,34 Although a few studies have paid attention to the influence of hypoxia on unsorted cancer cells,15,16,35,36 these studies could not identify the role of hypoxia on non-CSCs, because the increased expression of CD133, SOX-2 or OCT-4 under hypoxia may be from CSCs themselves.
Furthermore, the unwanted organelle material would be degraded through the lysosomal machinery during depletion because of increased expression of LC3B.
We showed previously that adult forebrain stem cell function declines during aging because of increased expression of let-7 microRNAs, evolutionarily conserved heterochronic genes that reduce HMGA2 expression.
In CKD, the kidney may be particularly sensitive to the adverse effects of aldosterone because of increased expression of the mineralocorticoid receptor and of sgk-1 [ 15].
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