Sentence examples for because in vitro studies from inspiring English sources

Because in vitro studies of gene transfer into hematopoietic progenitor cells and long-term culture-initiation cells have not been predictive of the efficiency of gene transfer into marrow-repopulating cells in vivo, studies that examine clinically applicable approaches to in utero gene therapy in appropriate animal models are still needed.

Pyronaridine is especially interesting as a component of ACT because in vitro studies using recent isolates indicate potent activity against chloroquine-resistant P. vivax and P. falciparum [20].

Because in vitro studies suggested that IFN-γ prevents bacterial escape from the phagosomes of infected macrophages, it is likely that such indirect mechanism is accounting for this IFN-γ-dependent L.m killing in vivo [39].

RAS mutations are of particular interest because in vitro studies indicate that their presence may imply a paradoxical effect of BRAF inhibitors.

It is unclear whether low maternal TSH affects fetal health because in vitro studies suggest that human placental permeability to TSH is limited (Bajoria and Fisk 1998).

Because in vitro studies cannot fully reflect the complexity of cytotoxicity of PCBs, we further investigated the role of PCBs on intestinal integrity using an intact physiological model.

A bi-exponential model to fit the curves reported in Fig. 2b and c can be ruled out because previous in vitro studies [20, 21], testing bi-exponential fitting functions in T2 decays, demonstrated a negligible component with a very short time constant and a predominant component with a time constant comparable to the mono-exponential fitting relaxation time.

Because the in vitro studies were examined for short periods, the long-term effect of either ERL or TRA was studied using an EC xenograft in vivo model.

In the present study we also documented concentrations of HO-PCBs and PCP because several in vitro studies have revealed their potency in competitively inhibiting T4 binding to TTR (van den Berg 1990).

Because the in vitro studies were carried out for short-term periods, we further evaluated in vivo the long-term effect of G28UCM, a novel pharmacological inhibitor of FASN.

Because previous in vitro studies have demonstrated a benefit of NAC and antioxidants in preventing rotenone toxicity in human cell lines [ 4- 6], she was treated with intravenous NAC (standard Prescott protocol 1979) and other antioxidants (including multivitamins, 5 ml/day ketovite [orally] and 125 mg zinc sulphate three times daily [orally]) empirically.