Sentence examples for because high expression of from inspiring English sources

We chose to pursue ALDH expression because high expression of ALDH is thought to provide a survival advantage in a toxic cellular microenvironment, and studies have demonstrated high ALDH expression in CSC from breast and colorectal carcinomas.

This mechanism is specific for MLL fusion leukemia because high expression of Hoxa9 and other possible factors act jointly to recruit EZH2 to the p16 TSS.

These results are relevant to in vivo progression because high expression of a novel MCF10DCIS-derived HGF signature was correlated with the basal-like subtype, with approximately 86% of basal-like cancers highly expressing the HGF signature, and because high expression of HGF signature was associated with poor survival.

This is interesting because high expression of IL-15 is found both in the synovial fluid and serum of RA patients and has been found to attract and activate T-cells, thereby contributing to the pathogenesis of RA [ 163].

Because high expression of type II collagen is of importance for the properties of cartilage after transplantation, we investigated whether the growth factor BMP-2 may modulate the chondrogenic phenotype in monolayer cell cultures (2D) and in three-dimensional culture (3D) systems.

Because high expression of HSP90AA1, HSP90AB1 and HSF1 was driven by amplification, and high-level amplification of HSF1 was associated with higher expression of HSP90 in un-amplified HSP90 samples, we defined up-regulated HSP90 as a collection of samples with the top 10% high expression value of HSP90AA1 and/or HSP90AB1, and the top 20% higher expression of HSF1.

The latter possibility is more parsimonious because highest expression of Cer elements was observed in muscle and testis; both tissues are known to be colonized by parasitic flatworms [ 76, 77].

This approach also has certain limitations due to potential involvement of the same miRNA in diseases of various organs and because higher expression of miRNA in an affected organ is not necessarily accompanied by an increase in its plasma level [ 53, 54].

Because high expression levels of miR-125b led to AI resistance and activation of the AKT/mTOR pathway in breast cancer cells and were also associated with poor prognosis among our cohort, we hypothesized that acquisition of deregulated miR-125b expression represents an alternative trick used by HR+ AI-resistant breast cancer cells to activate this crucial survival pathway.

In vivo however, insulin only increases p-Akt2 probably because of high expression of SH2-phophatase that selectively dephosphorylates p-Akt1, but not p-Akt2 in skeletal muscle [23].

Because of high expression of Slit1 and Slit2 on the axons that guide migrating GnRH neurons to the FB (Fig. 1; supplementary material Fig. S1), we also analysed the appearance of OLF/VN axons.