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Because gene expression patterns and metabolomic profiles also react in different ways to variation in diet and genotype, they each provide distinct perspectives regarding the mechanisms linking environment and genotype to gross phenotypes.
They are also likely to underestimate statistical significance both because gene expression patterns in the target genomes were inferred based on homology to D. mel genes and because the P values are calculated based on the assumption that candidate CRMs regulate their nearest neighboring genes.
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Because the gene expression patterns are different in different cell lines (Fig. 1), we analyzed the mRNA levels of different ISG candidates in different cell lines based on the microarray results.
Because the gene expression patterns of nonobese hepatic steatosis in affected patients remain unclear, we sought to explore these patterns using an animal model of nonobese hepatic steatosis.
Experimental [ 21] and theoretical [ 22] studies hint that gene regulatory circuits harbor latent phenotypes because their gene expression patterns often vary when a circuit is exposed to distinct external stimuli.
However, we classified it into the myelogenous origin because it exhibits gene expression patterns more similar to AML than ALL (Table 3; data not shown).
For example, because changes in gene expression patterns can have various forms, different statistical measures (and their thresholds) for finding DEGs and thus the corresponding functional modules should be further explored.
The prostate cancer cell line PC3 and primary epithelial EP156T cells were selected for profiling because the changed epigenetic gene expression patterns between them were similar to prostate cancer vs benign tissues in vivo (Figure 1).
Brinsmade et al. excluded several genes from their analyses because of their complex gene expression patterns.
Distinguishing transposition from gene removal is critical because potential changes in gene expression patterns are different under these two scenarios.
Furthermore, we analysed the normal mucosa and the tumour tissues from the right and left colon separately because of their distinct gene expression patterns (Glebov et al, 2003; Birkenkamp-Demtroder et al, 2005).
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