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[ 13] We were unable to explore this because few trials specified the date when they started recruitment.
This proved not to be possible because few trials reported dispersion (standard deviation, standard error, or interquartile range).
Furthermore, because few trials followed participants beyond one year, we cannot report here on weight gain beyond this time point.
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The PRECIS instrument was developed because "very few trials are purely pragmatic or explanatory" but rather vary along a continuum within key domains [ 41].
Sex is an important risk factor for laryngeal oedema after extubation and subsequent reintubation, but we could not do a subgroup analysis because so few trials reported results separately by sex.
This was not done with the current update because there were few trials that assessed the primary outcome.
However, the current clinical evidence remains limited because only a few trials for each of the considered treatment regimens (standard-duration and response-guided therapy) and patient groups (naïve and experienced) exist.
A funnel plot for publication bias could not be performed because there were too few trials to analyze with the Egger test.
We did not carry out these analyses because there were too few trials in the analyses.
Different observers may get different results, but previous studies on observer variation have not been informative, because of few observers, few trials, or few data.
This is because there are too few trials and there are not enough people with the right skills to run trials.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com