SZRD seems generally safe, but is insufficient evidence to make conclusions on the safety because fewer studies reported the adverse events.
No data on harm (for example, superinfection, resistance rates) were extracted because very few studies reported such data.
Some mutation subtypes are likely underestimated because only few studies reported extensive mutation analyses of all five genes, by both exonic sequencing and dosage analyses.
For example, because only a few studies reported information on most of the predictor variables simultaneously, we could not conduct multivariate meta-regression analyses.
This was necessary because there are only a few studies reported to date using plasmonic photothermal therapy after an intratumoral injection, and no consensus exists regarding the gold content needed to reproducibly resorb a tumor of a given tumor size.
(Additional file 2: Figure S2) Because different evaluation criteria were used and very few studies reported the results, we did not combine the data.
A few studies reported that hookah is not harmful [ 45, 46] because of the conviction that the smoke gets filtered in the water [ 47].
A few studies reported that the mothers had a history of psychosomatic illnesses; others equivocated.
Few studies reported the change in overjet immediately following intrusion.
Few studies reported the percentage of nonagenarians in ICU admissions.
